The Association of Unintentional Changes in Weight, Body Composition, and Homeostasis Model Assessment Index with Glycemic Progression in Non-Diabetic Healthy Subjects
Diabetes & Metabolism Journal
;
: 138-148, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-187623
ABSTRACT
BACKGROUND:
We performed a retrospective longitudinal study on the effects of changes in weight, body composition, and homeostasis model assessment (HOMA) indices on glycemic progression in subjects without diabetes during a four-year follow-up period in a community cohort without intentional intervention.METHODS:
From 28,440 non-diabetic subjects who participated in a medical check-up program in 2004, data on anthropometric and metabolic parameters were obtained after four years in 2008. Body composition analyses were performed with a bioelectrical impedance analyzer. Skeletal muscle index (SMI, %) was calculated with lean mass/weightx100. Subjects were divided into three groups according to weight change status in four years weight loss ( or =5.0%). Progressors were defined as the subjects who progressed to impaired fasting glucose or diabetes.RESULTS:
Progressors showed worse baseline metabolic profiles compared with non-progressors. In logistic regression analyses, the increase in changes of HOMA-insulin resistance (HOMA-IR) in four years presented higher odds ratios for glycemic progression compared with other changes during that period. Among the components of body composition, a change in waist-hip ratio was the strongest predictor, and SMI change in four years was a significant negative predictor for glycemic progression. Changes in HOMA beta-cell function in four years was a negative predictor for glycemic progression.CONCLUSION:
Increased interval changes in HOMA-IR, weight gain and waist-hip ratio was associated with glycemic progression during a four-year period without intentional intervention in non-diabetic Korean subjects.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Estado Prediabético
/
Composición Corporal
/
Peso Corporal
/
Aumento de Peso
/
Pérdida de Peso
/
Modelos Logísticos
/
Oportunidad Relativa
/
Estudios Retrospectivos
/
Estudios de Cohortes
/
Estudios de Seguimiento
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Idioma:
Inglés
Revista:
Diabetes & Metabolism Journal
Año:
2011
Tipo del documento:
Artículo
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