Mechanism of Anti-α-Synuclein Immunotherapy
Journal of Movement Disorders
;
: 14-19, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-187648
ABSTRACT
Immunization therapy targeting α-synuclein has emerged as a promising approach for Parkinson's disease and perhaps for other synucleinopathies. Several antibodies have shown therapeutic effects in mouse models of synucleinopathies and have alleviated the pathological and behavioral phenotypes of these mice. The mechanisms through which the immunization therapy works were initially puzzling, especially given that α-synuclein is a typical cytosolic protein. Recent studies, however, suggested that extracellular α-synuclein is an important pathogenic entity, and hence, a target for immunotherapy. Here, we review the literature describing immunization therapy for synucleinopathies in mouse models and provide current thoughts on the potential mechanisms underlying the therapeutic effects of α-synuclein immunotherapy.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Enfermedad de Parkinson
/
Fenotipo
/
Inmunización
/
Citosol
/
Usos Terapéuticos
/
Inmunoterapia
/
Anticuerpos
Límite:
Animales
Idioma:
Inglés
Revista:
Journal of Movement Disorders
Año:
2016
Tipo del documento:
Artículo
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