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Immunosuppression status of liver transplant recipients with hepatitis C affects biopsy-proven acute rejection
Clinical and Molecular Hepatology ; : 366-371, 2016.
Artículo en Inglés | WPRIM | ID: wpr-188163
ABSTRACT
BACKGROUND/

AIMS:

The relationship between patient survival and biopsy-proven acute rejection (BPAR) in liver transplant recipients with hepatitis C remains unclear. The aims of this study were to compare the characteristics of patients with and without BPAR and to identify risk factors for BPAR.

METHODS:

We retrospectively reviewed the records of 169 HCV-RNA-positive patients who underwent LT at three centers.

RESULTS:

BPAR occurred in 39 (23.1%) of the HCV-RNA-positive recipients after LT. The 1-, 3-, and 5-year survival rates were 92.1%, 90.3%, and 88.5%, respectively, in patients without BPAR, and 75.7%, 63.4%, and 58.9% in patients with BPAR (P<0.001). Multivariate analyses showed that BPAR was associated with the non-use of basiliximab and tacrolimus and the use of cyclosporin in LT recipients with HCV RNA-positive.

CONCLUSION:

The results of the present study suggest that the immunosuppression status of HCV-RNA-positive LT recipients should be carefully determined in order to prevent BPAR and to improve patient survival.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Recurrencia / Biopsia / Proteínas Recombinantes de Fusión / ARN Viral / Reacción en Cadena de la Polimerasa / Tasa de Supervivencia / Estudios Retrospectivos / Trasplante de Hígado / Tacrolimus / Ciclosporina Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Humanos Idioma: Inglés Revista: Clinical and Molecular Hepatology Año: 2016 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Recurrencia / Biopsia / Proteínas Recombinantes de Fusión / ARN Viral / Reacción en Cadena de la Polimerasa / Tasa de Supervivencia / Estudios Retrospectivos / Trasplante de Hígado / Tacrolimus / Ciclosporina Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Humanos Idioma: Inglés Revista: Clinical and Molecular Hepatology Año: 2016 Tipo del documento: Artículo