Combined Chemoradiation of Advanced Pancreatic Cancer / 대한암학회지
Journal of the Korean Cancer Association
;
: 300-305, 1998.
Artículo
en Coreano
| WPRIM
| ID: wpr-188247
ABSTRACT
PURPOSE:
This study was designed to evaluate the survival rate and prognostic factor of patients with advanced pancreatic cancer who received chemoirradiation. MATERIAL ANDMETHODS:
From March 1993 to November 1995, twenty patients with unresectable pancreatic cancer were treated at the Department of Therapeutic Radiology, St Mary's Hospital, Catholic University Medical College. There were 11 men and 9 women. Age at diagnosis ranged from 34 to 75 years. All patient were treated according to a protocol consisting of 40 Gy external radiation by split course concomitant with intravenous 5-fluorouracil (5-FU) 500 mg/m2 given in a bolus injection 4 hours before radiatian on each of the first 3 days of each treatment course. Among them, 5 patients received incomplete radiotherapy. The follow-up period ranged from 1.3 to 29 months.RESULTS:
In all the patients, median survival is 5.0 months and one and two-year overall survival rate was 34.3% and 25.8%, respectively. Median survival was 9.0 months and one-year survival rate was 33.3% in 15 patients with complete radiotherapy. The significant prognostic factors were stage, tumor location, and completion of chemoradio- therapy(p < 0.05).CONCLUSION:
A combination of radiotherapy and chemotherapy resulted in improved median survival. However, the significant prognostic factars affecting survival rate in this analysis need to be verified further through randomized trial.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias Pancreáticas
/
Radioterapia
/
Tasa de Supervivencia
/
Estudios de Seguimiento
/
Oncología por Radiación
/
Diagnóstico
/
Quimioterapia
/
Fluorouracilo
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio diagnóstico
/
Guía de Práctica Clínica
/
Estudio observacional
/
Estudio pronóstico
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Journal of the Korean Cancer Association
Año:
1998
Tipo del documento:
Artículo
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