Maturation of bone marrow-derived dendritic cells by a novel beta-glucan purified from Paenibacillus polymyxa JB115
Journal of Veterinary Science
;
: 187-189, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-189394
ABSTRACT
We investigated the immunostimulatory effects of a novel beta-glucan purified from Paenibacillus (P.) polymyxa JB115 on bone marrow-derived dendritic cells (DCs), a type of potent antigen-presenting cells. beta-glucan isolated from P. polymyxa JB115 enhanced the viability and induced the maturation of DCs. beta-glucan markedly increased the cytokine production of DCs and surface expression of DC markers. In addition, DCs treated with beta-glucan showed a higher capacity to stimulate allogeneic spleen cell proliferation compared to those treated with medium alone. These results demonstrate the effect of beta-glucan on DC maturation and may increase the use of beta-glucan.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Células Dendríticas
/
Células de la Médula Ósea
/
Supervivencia Celular
/
Inmunofenotipificación
/
Factor de Necrosis Tumoral alfa
/
Interleucina-12
/
Beta-Glucanos
/
Paenibacillus
/
Citometría de Flujo
/
Ratones Endogámicos BALB C
Límite:
Animales
Idioma:
Inglés
Revista:
Journal of Veterinary Science
Año:
2011
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS