Your browser doesn't support javascript.
loading
Mutation of the Chk1 Gene in Gastric Cancers with Microsatellite Instability
Journal of the Korean Gastric Cancer Association ; : 260-265, 2005.
Artículo en Coreano | WPRIM | ID: wpr-189860
ABSTRACT

PURPOSE:

The protein kinase Chk1 is required for cell cycle arrest in response to DNA damage and is shown to play an important role in the G2/M checkpoint. The aim of this study was to investigate the relationship between microsatellite instability and frameshift mutation of the Chk1 gene in gastric cancers. MATERIALS AND

METHODS:

The microsatellite instability was analyzed in 95 primary gastric carcinomas by using microdissection and 6 microsatellite markers. We also performed single strand conformational polymorphism and sequencing to detect frameshift mutation of the Chk1 gene.

RESULTS:

We found positive microsatellite instability in 19 (20%) of the 95 gastric cancers, 13 high- and 6 low-frequency microsatellite instability cases. The frameshift mutation of Chk1, which resulted in a truncated Chk1 protein, was detected in two high-frequency microsatellite instability cases.

CONCLUSION:

These data suggest that the microsatellite instability may contribute to the development of gastric carcinomas through inactivation of Chk1.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Proteínas Quinasas / Neoplasias Gástricas / Daño del ADN / Ciclo Celular / Mutación del Sistema de Lectura / Repeticiones de Microsatélite / Microdisección / Inestabilidad de Microsatélites / Puntos de Control del Ciclo Celular Idioma: Coreano Revista: Journal of the Korean Gastric Cancer Association Año: 2005 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Proteínas Quinasas / Neoplasias Gástricas / Daño del ADN / Ciclo Celular / Mutación del Sistema de Lectura / Repeticiones de Microsatélite / Microdisección / Inestabilidad de Microsatélites / Puntos de Control del Ciclo Celular Idioma: Coreano Revista: Journal of the Korean Gastric Cancer Association Año: 2005 Tipo del documento: Artículo