Tumor Angiogenesis as a Predictor of Malignancy Potential and Prognosis in Gastric Carcinoma / 대한암학회지
Journal of the Korean Cancer Association
;
: 19-25, 2000.
Artículo
en Coreano
| WPRIM
| ID: wpr-189985
ABSTRACT
PURPOSE:
In order to evaluate the clinical relevance of angiogenesis in patients with gastric cancer, we investigated the microvessel count in gastric cancer tissues and compared the results with several clinicopathologic factors and prognosis. MATERIALS ANDMETHODS:
A total of 256 patients with gastric cancer who underwent curative surgery were included in this study. Microvessel count was determined by im-munohistochemical staining using monoclonal antibody against factor VIII-related antigen.RESULTS:
The statistical significance between the microvessel count and clinicopathologic factors (age, sex, tumor invasion, lymph node involvement, histologic type) was analized. The tumor stage and histologic type were correlated with microvessel count. And also there was statistical significance with survival rate and recurrence-free survival rate between high (microvessel count> or =42) and low angiogeneic group (microvessel count< 42). The Cox's proportional hazard model showed that stage, histologic type, angiogeneic score were one of the significant and independent prognostic variables.CONCLUSION:
The tumor angiogenesis of gastric carcinoma may be independent prognostic factor for predicting recurrence and survival.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Recurrencia
/
Neoplasias Gástricas
/
Factor de von Willebrand
/
Modelos de Riesgos Proporcionales
/
Tasa de Supervivencia
/
Microvasos
/
Ganglios Linfáticos
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Cancer Association
Año:
2000
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS