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Effect of Probiotics on Symptoms in Korean Adults with Irritable Bowel Syndrome
Gut and Liver ; : 101-107, 2009.
Artículo en Inglés | WPRIM | ID: wpr-190163
ABSTRACT
BACKGROUND/

AIMS:

Irritable bowel syndrome (IBS) is a troublesome disease. Some strains of probiotics reportedly exert remarkable immunomodulatory effects, and so we designed a prospective double-blind randomized placebo-controlled clinical study to assess their effects in Korean adults with IBS.

METHODS:

IBS patients who met Rome III criteria were randomly assigned to receive composite probiotics or placebo. A total of 20 billion lyophilized bacteria were administered twice daily for 8 weeks. Primary outcome variables were symptom scores consisting of abdominal pain, flatulence, defecation discomfort, and sum of symptom scores. A visual analogue scale was used to quantify the severity. Secondary outcome variables consisted of the quality of life and bowel habits including defecation frequency and stool form.

RESULTS:

Thirty-six and 34 patients were randomized to the probiotics and placebo groups, respectively. Intention- to-treat analysis showed significant reductions in pain after 8 weeks of treatment -31.9 and -17.7 in the probiotics and placebo groups, respectively (p=0.045). The reductions in abdominal pain, defecation discomfort, and sum of scores were more significant in 58 patients with a score of at least 3 on the baseline stool-form scale.

CONCLUSIONS:

Composite probiotics containing Bifidobacterium bifidum BGN4, Lactobacillus acidophilus AD031, and other species are safe and effective, especially in patients who excrete normal or loose stools.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Calidad de Vida / Ciudad de Roma / Bacterias / Bifidobacterium / Dolor Abdominal / Estudios Prospectivos / Probióticos / Defecación / Síndrome del Colon Irritable / Flatulencia Tipo de estudio: Ensayo Clínico Controlado / Estudio diagnóstico / Estudio observacional Límite: Adulto / Humanos País/Región como asunto: Europa Idioma: Inglés Revista: Gut and Liver Año: 2009 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Calidad de Vida / Ciudad de Roma / Bacterias / Bifidobacterium / Dolor Abdominal / Estudios Prospectivos / Probióticos / Defecación / Síndrome del Colon Irritable / Flatulencia Tipo de estudio: Ensayo Clínico Controlado / Estudio diagnóstico / Estudio observacional Límite: Adulto / Humanos País/Región como asunto: Europa Idioma: Inglés Revista: Gut and Liver Año: 2009 Tipo del documento: Artículo