Effect of Probiotics on Symptoms in Korean Adults with Irritable Bowel Syndrome
Gut and Liver
;
: 101-107, 2009.
Artículo
en Inglés
| WPRIM
| ID: wpr-190163
ABSTRACT
BACKGROUND/AIMS:
Irritable bowel syndrome (IBS) is a troublesome disease. Some strains of probiotics reportedly exert remarkable immunomodulatory effects, and so we designed a prospective double-blind randomized placebo-controlled clinical study to assess their effects in Korean adults with IBS.METHODS:
IBS patients who met Rome III criteria were randomly assigned to receive composite probiotics or placebo. A total of 20 billion lyophilized bacteria were administered twice daily for 8 weeks. Primary outcome variables were symptom scores consisting of abdominal pain, flatulence, defecation discomfort, and sum of symptom scores. A visual analogue scale was used to quantify the severity. Secondary outcome variables consisted of the quality of life and bowel habits including defecation frequency and stool form.RESULTS:
Thirty-six and 34 patients were randomized to the probiotics and placebo groups, respectively. Intention- to-treat analysis showed significant reductions in pain after 8 weeks of treatment -31.9 and -17.7 in the probiotics and placebo groups, respectively (p=0.045). The reductions in abdominal pain, defecation discomfort, and sum of scores were more significant in 58 patients with a score of at least 3 on the baseline stool-form scale.CONCLUSIONS:
Composite probiotics containing Bifidobacterium bifidum BGN4, Lactobacillus acidophilus AD031, and other species are safe and effective, especially in patients who excrete normal or loose stools.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Calidad de Vida
/
Ciudad de Roma
/
Bacterias
/
Bifidobacterium
/
Dolor Abdominal
/
Estudios Prospectivos
/
Probióticos
/
Defecación
/
Síndrome del Colon Irritable
/
Flatulencia
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio diagnóstico
/
Estudio observacional
Límite:
Adulto
/
Humanos
País/Región como asunto:
Europa
Idioma:
Inglés
Revista:
Gut and Liver
Año:
2009
Tipo del documento:
Artículo
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