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Neuroprotective Effect of Growth Hormone in Neonatal Rat with Hypoxic Ischemic Brain Injury / 대한소아내분비학회지
Journal of Korean Society of Pediatric Endocrinology ; : 147-153, 2001.
Artículo en Coreano | WPRIM | ID: wpr-190209
ABSTRACT

PURPOSE:

To investigate the neuroprotective effect of growth hormone(GH) on neuronal cell necrosis and apoptosis at 1 week and 3 weeks after hypoxic ischemic brain injury.

METHODS:

Sprague-Dawley rats, seven-day-old, were used. Rats were anesthetized with ether less than 5 minutes. The right carotid artery was cut between double ligation. And then, rats were allowed to recover for 30 minutes followed by exposure to 8% oxygen at 37 degrees C for 2 hours for hypoxic ischemic insult. The study group was divided into 2 groups, control group(N=3) and GH treated group(N=3). GH treated group received intraperitoneal injection of GH 1 IU 2 hours after hypoxic ischemic insult following daily adminstration as same dose for 5 days. Rats were decapitated at 1 week and 3 weeks after hypoxic ischemic brain injury. After then, right hippocampal CA1 and CA3 neurons of rat brains were examined.

RESULTS:

Necrosis was significantly less in GH treated group than control group, and was more prominent at 3 weeks in both groups. The apoptosis was not found in GH treated and control group.

CONCLUSION:

GH has a neuroprotective effect on neuronal cell deaths(especially necrosis) from 1 week to 3 week after hypoxic ischemic insult in neonatal rat.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oxígeno / Encéfalo / Lesiones Encefálicas / Hormona del Crecimiento / Arterias Carótidas / Grupos Control / Ratas Sprague-Dawley / Apoptosis / Fármacos Neuroprotectores / Éter Límite: Animales Idioma: Coreano Revista: Journal of Korean Society of Pediatric Endocrinology Año: 2001 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oxígeno / Encéfalo / Lesiones Encefálicas / Hormona del Crecimiento / Arterias Carótidas / Grupos Control / Ratas Sprague-Dawley / Apoptosis / Fármacos Neuroprotectores / Éter Límite: Animales Idioma: Coreano Revista: Journal of Korean Society of Pediatric Endocrinology Año: 2001 Tipo del documento: Artículo