Neuroprotective Effect of Growth Hormone in Neonatal Rat with Hypoxic Ischemic Brain Injury / 대한소아내분비학회지
Journal of Korean Society of Pediatric Endocrinology
;
: 147-153, 2001.
Artículo
en Coreano
| WPRIM
| ID: wpr-190209
ABSTRACT
PURPOSE:
To investigate the neuroprotective effect of growth hormone(GH) on neuronal cell necrosis and apoptosis at 1 week and 3 weeks after hypoxic ischemic brain injury.METHODS:
Sprague-Dawley rats, seven-day-old, were used. Rats were anesthetized with ether less than 5 minutes. The right carotid artery was cut between double ligation. And then, rats were allowed to recover for 30 minutes followed by exposure to 8% oxygen at 37 degrees C for 2 hours for hypoxic ischemic insult. The study group was divided into 2 groups, control group(N=3) and GH treated group(N=3). GH treated group received intraperitoneal injection of GH 1 IU 2 hours after hypoxic ischemic insult following daily adminstration as same dose for 5 days. Rats were decapitated at 1 week and 3 weeks after hypoxic ischemic brain injury. After then, right hippocampal CA1 and CA3 neurons of rat brains were examined.RESULTS:
Necrosis was significantly less in GH treated group than control group, and was more prominent at 3 weeks in both groups. The apoptosis was not found in GH treated and control group.CONCLUSION:
GH has a neuroprotective effect on neuronal cell deaths(especially necrosis) from 1 week to 3 week after hypoxic ischemic insult in neonatal rat.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Oxígeno
/
Encéfalo
/
Lesiones Encefálicas
/
Hormona del Crecimiento
/
Arterias Carótidas
/
Grupos Control
/
Ratas Sprague-Dawley
/
Apoptosis
/
Fármacos Neuroprotectores
/
Éter
Límite:
Animales
Idioma:
Coreano
Revista:
Journal of Korean Society of Pediatric Endocrinology
Año:
2001
Tipo del documento:
Artículo
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