Serum Cystatin C Reflects the Progress of Albuminuria
Diabetes & Metabolism Journal
;
: 602-609, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-191388
ABSTRACT
BACKGROUND:
Research on the relationship between urinary albumin excretion and serum cystatin C in diabetes is restricted to cross-sectional studies. In this study, we investigated how well serial measurements of serum cystatin C level reflect changes in the urinary albumin excretion rate.METHODS:
We enrolled and retrospectively collected data on 1,058 participants with type 2 diabetes who were older than 18 years and who had more than 3 years of follow-up with serial measurements of albuminuria and serum cystatin C at an outpatient clinic.RESULTS:
With the use of a linear mixed model, we found that the albuminuria level for each patient over time corresponded with the annual change in serum cystatin C-based estimated glomerular filtration rate (cysC-eGFR) but did not correspond with the creatinine-based eGFR calculated by the modification of diet in renal disease formula (MDRD-eGFR). The discrepancy in the direction of the trend was smaller with cysC-eGFR than with MDRD-eGFR.CONCLUSION:
Serum cystatin C level reflects the trend in albuminuria level more accurately than serum creatinine level in Korean type 2 diabetes mellitus patients.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pacientes Ambulatorios
/
Estudios Retrospectivos
/
Estudios de Seguimiento
/
Creatinina
/
Diabetes Mellitus Tipo 2
/
Nefropatías Diabéticas
/
Dieta
/
Albuminuria
/
Cistatina C
/
Tasa de Filtración Glomerular
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Diabetes & Metabolism Journal
Año:
2011
Tipo del documento:
Artículo
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