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Effect of Long-Term Administration of Secretory Suppressives on Rat Pancreas (1)
Yonsei Medical Journal ; : 19-24, 1969.
Artículo en Inglés | WPRIM | ID: wpr-191414
ABSTRACT
Atropine (2.5 mg/kg), hexamethonium (1 mg/kg), Trasylol (1,000 u/kg), acetazolamide (100 mg/kg), cortisone (5 mg /kg) or procaine (5 mg/kg) were injected intraperitoneally once a day for 21 days into rats (both sexes) fed a low protein diet. The rats were fasted and sacrificed 24 hr after the last injection. Atropine and cortisone, but not the other agents, cause a significant increase in both pancreatic weight and enzymes. Serum amylase increased markedly in the cortisone group and serum GOT and GPT increased but slightly in the atropine group. Enlargement of the pancreatic acini, cellular hypertrophy and increases of zymogen granules were observed in all the groups except the procaine and normal control group. The hypertrophy of acini was more prominent in the atropine and cortisone groups. None of drugs used could induce decrease or depress the enzyme formation and weight of pancreas. This data indicates that long-term administration of these drugs, particularly atropine, cortisone or even other Ragents may induce preferential formation of pancreatic enzymes to exocrine secretions and consequently may cause enlargement of the pancreatic acini.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Tamaño de los Órganos / Páncreas / Procaína / Aspartato Aminotransferasas / Atropina / Factores de Tiempo / Cortisona / Aprotinina / Alanina Transaminasa / Compuestos de Hexametonio Límite: Animales Idioma: Inglés Revista: Yonsei Medical Journal Año: 1969 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Tamaño de los Órganos / Páncreas / Procaína / Aspartato Aminotransferasas / Atropina / Factores de Tiempo / Cortisona / Aprotinina / Alanina Transaminasa / Compuestos de Hexametonio Límite: Animales Idioma: Inglés Revista: Yonsei Medical Journal Año: 1969 Tipo del documento: Artículo