TLR/MyD88-mediated Innate Immunity in Intestinal Graft-versus-Host Disease
Immune Network
;
: 144-151, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-191880
ABSTRACT
Graft-versus-host disease (GHVD) is a severe complication after allogeneic hematopoietic stem cell transplantation. The degree of inflammation in the gastrointestinal tract, a major GVHD target organ, correlates with the disease severity. Intestinal inflammation is initiated by epithelial damage caused by pre-conditioning irradiation. In combination with damages caused by donor-derived T cells, such damage disrupts the epithelial barrier and exposes innate immune cells to pathogenic and commensal intestinal bacteria, which release ligands for Toll-like receptors (TLRs). Dysbiosis of intestinal microbiota and signaling through the TLR/myeloid differentiation primary response gene 88 (MyD88) pathways contribute to the development of intestinal GVHD. Understanding the changes in the microbial flora and the roles of TLR signaling in intestinal GVHD will facilitate the development of preventative and therapeutic strategies.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Bacterias
/
Linfocitos T
/
Trasplante de Células Madre Hematopoyéticas
/
Tracto Gastrointestinal
/
Receptores Toll-Like
/
Disbiosis
/
Microbioma Gastrointestinal
/
Enfermedad Injerto contra Huésped
/
Inmunidad Innata
/
Inflamación
Idioma:
Inglés
Revista:
Immune Network
Año:
2017
Tipo del documento:
Artículo
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