Your browser doesn't support javascript.
loading
Analysis of reference interval and age-related changes in serum biochemistry and hematology in the specific pathogen free miniature pig / 한국실험동물학회지
Laboratory Animal Research ; : 245-253, 2012.
Artículo en Inglés | WPRIM | ID: wpr-192524
ABSTRACT
We analyzed 72 items related to serum biochemistry and hematology in 85 specific pathogen-free (SPF) Seoul National University (SNU) miniature pigs aged 1- to 36-months which originated from a Minnesota miniature pig. Almost all examined items were similar between male and female pigs. However, some items such as Cr level, B/C ratio, C.R.F, LDH, LAP and T4 were significantly different between male and female pigs (P<0.05). Thirty four examined items showed age-related changes, and the significant changes were observed in animals less than six months old. The values for BUN, K, uric acid, Ca, Ca++, and Pi were significantly higher in pigs younger than six months of age, which might reflect poor kidney function in young pigs. Additionally, TIBC, UIBC and RDW were significantly higher in young pigs, and RBC, Hb, HCT, MCHC and MCV were significantly lower in young pigs, thus indicating a similar physiology of iron deficiency anemia. These age-related specific phenotypes seemed to be normal, but it should be considered in the long-term experiment using the young pigs. In conclusion, in this study, we defined the normal reference intervals for SPF SNU miniature pigs, and we also determined that there are some physiological differences between the pig genders and ages. This study provides fundamental data for use in experiments involving SPF SNU miniature pigs.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fenotipo / Porcinos / Ácido Úrico / Bioquímica / Minnesota / Organismos Libres de Patógenos Específicos / Anemia Ferropénica / Hematología / Riñón Límite: Animales / Femenino / Humanos / Masculino País/Región como asunto: America del Norte Idioma: Inglés Revista: Laboratory Animal Research Año: 2012 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fenotipo / Porcinos / Ácido Úrico / Bioquímica / Minnesota / Organismos Libres de Patógenos Específicos / Anemia Ferropénica / Hematología / Riñón Límite: Animales / Femenino / Humanos / Masculino País/Región como asunto: America del Norte Idioma: Inglés Revista: Laboratory Animal Research Año: 2012 Tipo del documento: Artículo