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Mutagenic Assessment of Olmesartan Cilexetil by Bacterial Mutation Assay
Toxicological Research ; : 217-219, 2013.
Artículo en Inglés | WPRIM | ID: wpr-193671
ABSTRACT
Hypertension is a serious health problem due to high frequency and concomitant other diseases including cardiovascular and renal dysfunction. Olmesartan cilexetil is a new antihypertensive drug associated with angiotensin II receptor antagonist. This study was conducted to evaluate the mutagenicity of olmesartan cilexetil by bacterial reverse mutation test using Salmonella typhimurium (TA100, TA1535, TA98, and TA1537) and Escherichia coli (WP2 uvrA). At the concentrations of 0, 62, 185, 556, 1667, and 5000 microg/plate, olmesartan cilexetil was negative in both Salmonella typhimurium and Escherichia coli regardless of presence or absence of metabolic activation system (S9 mix). These results demonstrate that olmesartan cilexetil does not induce bacterial reverse mutation.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Salmonella typhimurium / Tetrazoles / Receptores de Angiotensina / Biotransformación / Escherichia coli / Hipertensión / Imidazoles Idioma: Inglés Revista: Toxicological Research Año: 2013 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Salmonella typhimurium / Tetrazoles / Receptores de Angiotensina / Biotransformación / Escherichia coli / Hipertensión / Imidazoles Idioma: Inglés Revista: Toxicological Research Año: 2013 Tipo del documento: Artículo