Supraphysiologic glucocorticoid administration increased biomechanical bone strength of rats' vertebral body / 한국실험동물학회지
Laboratory Animal Research
; : 180-187, 2015.
Article
en En
| WPRIM
| ID: wpr-193814
Biblioteca responsable:
WPRO
ABSTRACT
The aim of this study is to assess the effects of different glucocorticoid administration protocols on biomechanical properties of the first lumbar vertebral body in rats. We divided 40 male rats into the following groups: control, dexamethasone (7 mg/week), dexamethasone (0.7 mg/week), methylprednisolone (7 mg/kg/week), methylprednisolone (5 mg/kg twice weekly), dexamethasone (7 mg/kg three times per week), dexamethasone (0.7 mg/kg three times per week, and low-level laser treated rats. Lumbar vertebrae in rats were exposed to the pulsed laser. We conducted a biomechanical test to examine the mechanical properties of vertebral body in rats' lumbar bone. Supraphysiologic glucocorticoid administration protocols did not impair the biomechanical properties of rats' vertebral bodies compared to control and laser-treated rats. Supraphysiologic glucocorticoid administration caused an anabolic effect on the vertebral bodies.
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Índice:
WPRIM
Asunto principal:
Dexametasona
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Metilprednisolona
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Terapia por Luz de Baja Intensidad
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Anabolizantes
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Vértebras Lumbares
Límite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Laboratory Animal Research
Año:
2015
Tipo del documento:
Article