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The Interaction Between Allelic Variants of CD86 and CD40LG: A Common Risk Factor of Allergic Asthma and Rheumatoid Arthritis
Allergy, Asthma & Immunology Research ; : 137-141, 2014.
Artículo en Inglés | WPRIM | ID: wpr-19428
ABSTRACT

PURPOSE:

Allergic asthma (AA) and rheumatoid arthritis (RA) are immune tolerance-related diseases, and immune tolerance is known to be influenced by costimulatory molecules. In this study, we sought to identify common genetic susceptibility in AA and RA.

METHODS:

Two hundred cases of AA, 184 cases of RA, and 182 healthy controls were recruited at the Seoul National University Hospital, Seoul, Korea. Eight single nucleotide polymorphisms (SNPs) in five genes coding costimulatory molecules, namely, -318C>T, +49A>G, and 6230G>A in CTLA4, IVS3+17T>C in CD28, -3479T>G and I179V in CD86, -1C>T in CD40, and -3458A>G in CD40LG were scored, and genetic interactions were evaluated by multifactor dimensionality reduction (MDR) analysis.

RESULTS:

MDR analysis revealed a significant gene-gene interaction between -3479T>G CD86 and -3458A>G CD40LG for AA. Subjects with the T/T genotype of -3479T>G CD86 and the A/A genotype of -3458A>G CD40LG were found to be significantly more likely to develop AA than those with the T/T genotype of -3479T>G CD86 and A/- genotype of -3458A>G CD40LG (adjusted OR, 6.09; 95% CI, 2.89-12.98; logistic regression analysis controlled by age). Similarly those subjects showed a significant risk of developing RA (adjusted OR, 39.35; 95% CI, 15.01-107.00, logistic regression analysis controlled by age).

CONCLUSIONS:

Our findings suggest that a genetic interaction between CD86 and CD40LG favors the development of both AA and RA.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Polimorfismo Genético / Artritis Reumatoide / Asma / Modelos Logísticos / Factores de Riesgo / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Ligando de CD40 / Reducción de Dimensionalidad Multifactorial / Codificación Clínica Tipo de estudio: Estudio de etiología / Estudio pronóstico / Factores de riesgo País/Región como asunto: Asia Idioma: Inglés Revista: Allergy, Asthma & Immunology Research Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Polimorfismo Genético / Artritis Reumatoide / Asma / Modelos Logísticos / Factores de Riesgo / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Ligando de CD40 / Reducción de Dimensionalidad Multifactorial / Codificación Clínica Tipo de estudio: Estudio de etiología / Estudio pronóstico / Factores de riesgo País/Región como asunto: Asia Idioma: Inglés Revista: Allergy, Asthma & Immunology Research Año: 2014 Tipo del documento: Artículo