Kinetin inhibits apoptosis of aging spleen cells induced by D-galactose in rats
Journal of Veterinary Science
;
: 353-359, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-194863
ABSTRACT
Kinetin (Kn) is a cytokinin growth factor that exerts several anti-aging and antioxidant effects on cells and organs. To investigate the mechanism underlying apoptotic events in aging cells induced by D-galactose (D-gal), we examined the effect of Kn delivered via nuchal subcutaneous injection on D-gal-induced aging and apoptosis in rats. Our results showed that interleukin (IL)-2 levels and mitochondrial membrane potential (DeltaPsim) were decreased by Kn in aging rats while IL-6 production and apoptosis increased. In addition, the expression of anti-apoptotic Bcl-2 was low while that of Bax was high in the aging group. After treated with Kn, compared with aging group, there showed obvious difference in Kn group with elevated IL-2, proliferation index, Bcl-2, DeltaPsim and decreased IL-6 and Bax in splenic lymphocyte. Based on these results, we concluded that Kn can effectively protect the rat spleen from aging, apoptosis, and atrophy.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Bazo
/
Envejecimiento
/
Interleucinas
/
Interleucina-6
/
Apoptosis
/
Potencial de la Membrana Mitocondrial
/
Galactosa
/
Cinetina
Límite:
Animales
Idioma:
Inglés
Revista:
Journal of Veterinary Science
Año:
2014
Tipo del documento:
Artículo
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