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Improvement of Erdheim-Chester disease-related renal failure after treatment with anakinra
Kidney Research and Clinical Practice ; : 165-167, 2014.
Artículo en Inglés | WPRIM | ID: wpr-194867
ABSTRACT
Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis characterized by infiltrates of lipid-laden CD68+/CD1- histiocytes, affecting heart, lungs, central nervous system, and bones. Kidney and adjacent structures can also be affected, leading to renal failure in about 30% of cases. The diagnosis is challenging, and treatment is generally based on administration of interferon-alpha (IFNalpha), but preliminary results also showed the therapeutic efficacy of anakinra, an antagonist of the receptor of interleukin-1 (IL-1). We report the case of an elderly patient with ECD and severe involvement of the heart and kidneys who was successfully treated with anakinra.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Histiocitosis / Sistema Nervioso Central / Interleucina-1 / Interferón-alfa / Enfermedad de Erdheim-Chester / Diagnóstico / Insuficiencia Renal / Proteína Antagonista del Receptor de Interleucina 1 / Corazón / Histiocitos Tipo de estudio: Estudio diagnóstico Límite: Anciano / Humanos Idioma: Inglés Revista: Kidney Research and Clinical Practice Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Histiocitosis / Sistema Nervioso Central / Interleucina-1 / Interferón-alfa / Enfermedad de Erdheim-Chester / Diagnóstico / Insuficiencia Renal / Proteína Antagonista del Receptor de Interleucina 1 / Corazón / Histiocitos Tipo de estudio: Estudio diagnóstico Límite: Anciano / Humanos Idioma: Inglés Revista: Kidney Research and Clinical Practice Año: 2014 Tipo del documento: Artículo