Improvement of Erdheim-Chester disease-related renal failure after treatment with anakinra
Kidney Research and Clinical Practice
;
: 165-167, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-194867
ABSTRACT
Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis characterized by infiltrates of lipid-laden CD68+/CD1- histiocytes, affecting heart, lungs, central nervous system, and bones. Kidney and adjacent structures can also be affected, leading to renal failure in about 30% of cases. The diagnosis is challenging, and treatment is generally based on administration of interferon-alpha (IFNalpha), but preliminary results also showed the therapeutic efficacy of anakinra, an antagonist of the receptor of interleukin-1 (IL-1). We report the case of an elderly patient with ECD and severe involvement of the heart and kidneys who was successfully treated with anakinra.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Histiocitosis
/
Sistema Nervioso Central
/
Interleucina-1
/
Interferón-alfa
/
Enfermedad de Erdheim-Chester
/
Diagnóstico
/
Insuficiencia Renal
/
Proteína Antagonista del Receptor de Interleucina 1
/
Corazón
/
Histiocitos
Tipo de estudio:
Estudio diagnóstico
Límite:
Anciano
/
Humanos
Idioma:
Inglés
Revista:
Kidney Research and Clinical Practice
Año:
2014
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS