Analysis of factors affecting hemorrhagic diathesis and overall survival in patients with acute promyelocytic leukemia
The Korean Journal of Internal Medicine
; : 884-890, 2015.
Article
en En
| WPRIM
| ID: wpr-195230
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND/AIMS: This study investigated whether patients with acute promyelocytic leukemia (APL) truly fulfill the diagnostic criteria of overt disseminated intravascular coagulation (DIC), as proposed by the International Society on Thrombosis and Haemostasis (ISTH) and the Korean Society on Thrombosis and Hemostasis (KSTH), and analyzed which component of the criteria most contributes to bleeding diathesis. METHODS: A single-center retrospective analysis was conducted on newly diagnosed APL patients between January 1995 and May 2012. RESULTS: A total of 46 newly diagnosed APL patients were analyzed. Of these, 27 patients (58.7%) showed initial bleeding. The median number of points per patient fulfilling the diagnostic criteria of overt DIC by the ISTH and the KSTH was 5 (range, 1 to 7) and 3 (range, 1 to 4), respectively. At diagnosis of APL, 22 patients (47.8%) fulfilled the overt DIC diagnostic criteria by either the ISTH or KSTH. In multivariate analysis of the ISTH or KSTH diagnostic criteria for overt DIC, the initial fibrinogen level was the only statistically significant factor associated with initial bleeding (p = 0.035), but it was not associated with overall survival (OS). CONCLUSIONS: Initial fibrinogen level is associated with initial presentation of bleeding of APL patients, but does not affect OS.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Fibrinógeno
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Biomarcadores
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Leucemia Promielocítica Aguda
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Distribución de Chi-Cuadrado
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Modelos Logísticos
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Modelos de Riesgos Proporcionales
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Análisis Multivariante
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Estudios Retrospectivos
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Factores de Riesgo
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Coagulación Intravascular Diseminada
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
The Korean Journal of Internal Medicine
Año:
2015
Tipo del documento:
Article