Effect of Enflurane Anesthesia on Patients Treated with Isoniazid / 대한마취과학회지

ABSTRACT

Enflurane is metabolized in the liver by the hepatic microsomal enzyme system, cytochrome P-450 and induces enzyme during the enflurane exposure. Enhanced biotransformation might occur after enflurane itself and several other drugs, isoniazid (INH), ethanol and cholorpromazine. Increased inorganic fluroide, one of the enflurane metaboites, could impair renal function. The possibility of increased enflurane defluorination follwing treatment with isoniazid, isoniazid group (n=10) and control group (n= 11) was investigated by the measuring the serum and urine F in the preoperative period and 2 hrs after anesthesia, immediate postoperative and 24th postoperative hour. According to the serum inorganic fluoride concentration, the isoniazid group was divided again into INH high F- and INH low F- groups. In the preoperative, immediate postoperative period and 24th postoperative hour, the changes of renal function were measured by the BUN and creatinine and liver function was measured by the SGOT and SGPT. The results were as follows 1) Serum inorganic fluoride increased in enflurane anesthesia significantly in all three groups and decreased in the 24th postoperative hour. Among the three groups, enhanced defluorination was the highest in the INH high F group. 2) Urine inorganic fluoride was increased in the control and INH high F group. 3) There were no changes in renal and hepatic function after enflurane anesthesia. Our study indicated that enflurane does not harm the INH treated patient.