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Dopamine Transporter Gene and Dopamine D2, D3, D4 Receptor Gene Polymorphisms in Attention Deficit Hyperactivity Disorder
Journal of the Korean Academy of Child and Adolescent Psychiatry ; : 19-27, 2008.
Artículo en Coreano | WPRIM | ID: wpr-197043
ABSTRACT

OBJECTIVES:

The aim of this study was to examine the association of attention-deficit hyperactivity disorder (ADHD) in Korean populations with functional polymorphisms of six genes dopamine receptors (Ser311/Cys311 polymorphism, Taq1 A polymorphism, and Taq1 B polymorphism in DRD2, BalI polymorphism in DRD3, and promoter -521 C/T polymorphism and exon III 48 bp repeat polymorphism in DRD4) and one gene in dopamine transporter (DAT1).

METHODS:

Participants were 58 children with ADHD and 110 control children. The genotypes were determined by PCR.

RESULTS:

There was a statistically significant difference in genotype frequency of -521 C/T polymorphism within the promoter region of the DRD4 between two groups. Furthermore, in the male group, both genotype and allele frequencies showed statistically significant differences.

CONCLUSION:

Findings of the study indicate that -521 C/T polymorphism in promoter region of DRD4 appears to be a possible candidate gene for ADHD in Korean population.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Trastorno por Déficit de Atención con Hiperactividad / Dopamina / Exones / Receptores Dopaminérgicos / Regiones Promotoras Genéticas / Proteínas de Transporte de Dopamina a través de la Membrana Plasmática / Frecuencia de los Genes / Genotipo Límite: Niño / Humanos / Masculino Idioma: Coreano Revista: Journal of the Korean Academy of Child and Adolescent Psychiatry Año: 2008 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Trastorno por Déficit de Atención con Hiperactividad / Dopamina / Exones / Receptores Dopaminérgicos / Regiones Promotoras Genéticas / Proteínas de Transporte de Dopamina a través de la Membrana Plasmática / Frecuencia de los Genes / Genotipo Límite: Niño / Humanos / Masculino Idioma: Coreano Revista: Journal of the Korean Academy of Child and Adolescent Psychiatry Año: 2008 Tipo del documento: Artículo