Adenoviral mediated hepatocyte growth factor gene attenuates hyperglycemia and beta cell destruction in overt diabetic mice
Experimental & Molecular Medicine
;
: 494-500, 2003.
Artículo
en Inglés
| WPRIM
| ID: wpr-197473
ABSTRACT
Hepatocyte growth factor (HGF) is a potent mitogen and promoter of proliferation of insulin producing beta cells of pancreatic islets. To study the role of HGF, an adenoviral vector carrying the human HGF (Ad.hHGF) gene was transfected into the streptozotocin-induced diabetic mice and evaluated the effect on the blood glucose metabolism and the insulin-secreting beta cells of pancreatic islets. Ad.hHGF gene transfection resulted in amelioration of hyperglycemia and prolongation of survival period in the diabetic mice. Concomitantly adenoviral- mediated hHGF gene therapy slightly increased serum insulin concentration and the expression of insulin in the pancreatic islet. Although the proliferation of beta-cell mass was not noticeable, the beneficial effect of HGF is significant to an almost deteriorated pancreatic islets. Taken together, these data suggest that the Ad.hHGF gene therapy into diabetic mice may prevent the further destruction and present as a beneficial remedy for type 1 diabetic patients.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Glucemia
/
Peso Corporal
/
Proteínas Recombinantes
/
Terapia Genética
/
Adenoviridae
/
Tasa de Supervivencia
/
Islotes Pancreáticos
/
Factor de Crecimiento de Hepatocito
/
Diabetes Mellitus Experimental
/
Hiperglucemia
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Experimental & Molecular Medicine
Año:
2003
Tipo del documento:
Artículo
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