Five-Year Follow-up Study of Monoclonal Gammopathy of Undetermined Significance in a Korean Elderly Urban Cohort / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 215-220, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-198394
ABSTRACT
PURPOSE:
We previously reported the prevalence of monoclonal gammopathy of undetermined significance (MGUS) to be 3.3% among an elderly Korean urban cohort recruited during 2005-2006. Here, we report a 5-year follow-up study of the previously identified MGUS cohort. MATERIALS ANDMETHODS:
The 680 participants from the initial cohort were followed-up for a median of 5 years. Sera were collected between 2010 and 2011. Two-step screening was performed with standard serum electrophoresis followed by immunofixation and determination of the serum concentration of monoclonal-protein (M-protein).RESULTS:
Of the 680 participants (21 with MGUS), 348 (51%) agreed to participate in the follow-up study and 10 were found to have MGUS. Among the 21 MGUS patients initially identified, nine were followed-up, six had persistent M-protein, and one patient had progressed to multiple myeloma (progression rate, 1.0%/yr). The M-protein disappeared in the remaining two individuals. Among the 339 participants without MGUS who were followed-up, four developed an M-protein. There was no significant difference in survival with respect to the presence of MGUS (p=0.66).CONCLUSION:
The 5-year follow-up data show that the natural clinical course of MGUS in Korea is similar to that in Western countries. MGUS was not associated with an increased risk of death over the 5-year study period.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Gammopatía Monoclonal de Relevancia Indeterminada
/
Tamizaje Masivo
/
Prevalencia
/
Estudios de Cohortes
/
Estudios de Seguimiento
/
Electroforesis
/
Corea (Geográfico)
/
Mieloma Múltiple
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Estudio de prevalencia
/
Estudio pronóstico
/
Factores de riesgo
/
Estudio de tamizaje
Límite:
Anciano
/
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Cancer Research and Treatment
Año:
2015
Tipo del documento:
Artículo
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