Gemcitabine/Cisplatin Combination Chemotherapy in Advanced non-Small Cell lung Cancer / 결핵
Tuberculosis and Respiratory Diseases
;
: 98-106, 2003.
Artículo
en Coreano
| WPRIM
| ID: wpr-198704
ABSTRACT
BACKGROUND:
To evaluate the efficacy and safety of gemcitabine and cisplatin chemotherapy in advanced non-small cell lung cancer (NSCLC). MATERIALS ANDMETHODS:
Forty patients (21 men, 19 women ; age range, 37 to 73 years; median, 63 years) with unresectable stage IIIB to IV NSCLC were evaluated. Patients received cisplatin 60mg/m2 (Day 1), gemcitabine 1200mg/m2 (Day 1 and 8) every 21 days. Eighteen patients had stage IIIB disease and 22 had stage IV. There were 28 patients of adenocarcinoma (70.0%), 11 of squamous cell carcinoma (27.5%), and one of large cell carcinoma (2.5%).RESULTS:
Of 40 patients, no patients showed complete response while 15(37.5%) showed partial response, 7(17.5%) had stable diseases, 18(45%) had progressive diseases. During a total of 195 courses of chemotherapy, grade 3 or more granulocytopenia and thrombocytopenia occured in 12.5% and 2.5% of patients respectively. Non-hematologic toxicity was mild and easily controlled. There was one case of treatment-related death by pneumomia. The median survival was 55 weeks (95% CI, 34~75weeks), and the time to progression was 19 weeks (95% CI, 16~23weeks). One year survival rate was 55% and 2 year survival rate was 10%.CONCLUSION:
The efficacy of cisplatin and gemcitabine combination chemotherapy was acceptable in the treatment of advanced NSCLC.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Trombocitopenia
/
Carcinoma de Células Escamosas
/
Adenocarcinoma
/
Tasa de Supervivencia
/
Cisplatino
/
Carcinoma de Células Grandes
/
Carcinoma de Pulmón de Células no Pequeñas
/
Agranulocitosis
/
Quimioterapia
/
Quimioterapia Combinada
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Tuberculosis and Respiratory Diseases
Año:
2003
Tipo del documento:
Artículo
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