From rabbit antibody repertoires to rabbit monoclonal antibodies
Experimental & Molecular Medicine
;
: e305-2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-198937
ABSTRACT
In this review, we explain why and how rabbit monoclonal antibodies have become outstanding reagents for laboratory research and increasingly for diagnostic and therapeutic applications. Starting with the unique ontogeny of rabbit B cells that affords highly distinctive antibody repertoires rich in in vivo pruned binders of high diversity, affinity and specificity, we describe the generation of rabbit monoclonal antibodies by hybridoma technology, phage display and alternative methods, along with an account of successful humanization strategies.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Bacteriófagos
/
Linfocitos B
/
Sensibilidad y Especificidad
/
Hibridomas
/
Indicadores y Reactivos
/
Anticuerpos Monoclonales
Tipo de estudio:
Estudio diagnóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Experimental & Molecular Medicine
Año:
2017
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS