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A Case of Granulocyte-Colony Stimulating Factor-Producing Hepatocellular Carcinoma Confirmed by Immunohistochemistry
Journal of Korean Medical Science ; : 476-480, 2010.
Artículo en Inglés | WPRIM | ID: wpr-199408
ABSTRACT
Granulocyte-colony stimulating factor (G-CSF) is a naturally occurring glycoprotein that stimulates the proliferation and maturation of precursor cells in the bone marrow into fully differentiated neutrophils. Several reports of G-CSF-producing malignant tumors have been published, but scarcely any in the hepatobiliary system, such as in hepatocellular carcinoma (HCC). Here, we encountered a 69-yr-old man with a hepatic tumor who had received right hepatic resection. He showed leukocytosis of 25,450/microL along with elevated serum G-CSF. Histological examination of surgical samples demonstrated immunohistochemical staining for G-CSF, but not for G-CSF receptor. The patient survived without recurrence for four years, but ultimately passed away with multiple bone metastases. In light of the above, clinicians may consider G-CSF-producing HCC when encountering patients with leukocytosis and a hepatic tumor. More cases are needed to clarify the clinical picture of G-CSF-producing HCC.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Óseas / Factor Estimulante de Colonias de Granulocitos / Receptores de Factor Estimulante de Colonias de Granulocito / Resultado Fatal / Carcinoma Hepatocelular / Neoplasias Hepáticas Límite: Anciano / Humanos / Masculino Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Óseas / Factor Estimulante de Colonias de Granulocitos / Receptores de Factor Estimulante de Colonias de Granulocito / Resultado Fatal / Carcinoma Hepatocelular / Neoplasias Hepáticas Límite: Anciano / Humanos / Masculino Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2010 Tipo del documento: Artículo