Characteristics of Intron 6 Nucleotide Sequences of cis-AB in Koreans / 대한수혈학회지
Korean Journal of Blood Transfusion
;
: 230-235, 2010.
Artículo
en Coreano
| WPRIM
| ID: wpr-199580
ABSTRACT
BACKGROUND:
The cis-AB is a very rare phenotype in the ABO blood group system. It corresponds to a special ABO allele that encodes glycosyltransferase that is capable of synthesizing both A and B antigens. Until now, the exon 6 and 7 gene sequences of cis-AB alleles are well known. In this study, we report on the intron 6 sequence structure of the cis-AB allele.METHODS:
Standard serologic tests for the ABO blood group phenotypes were performed in four cis-AB samples. Allele-separation by cloning and subsequent sequencing was carried out.RESULTS:
The results showed that intron 6 of cis-AB is almost identical to the A101 allele except for three single nucleotide polymorphisms at nucleotide positions 163, 179 and 662, where the nucleotides of the A101 replace those of B101.CONCLUSION:
The intron 6 sequences of cis-AB in Koreans have both A101 and B101 blood group sequences.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fenotipo
/
Sistema del Grupo Sanguíneo ABO
/
Tipificación y Pruebas Cruzadas Sanguíneas
/
Pruebas Serológicas
/
Secuencia de Bases
/
Intrones
/
Exones
/
Células Clonales
/
Clonación de Organismos
/
Polimorfismo de Nucleótido Simple
Tipo de estudio:
Estudio diagnóstico
Idioma:
Coreano
Revista:
Korean Journal of Blood Transfusion
Año:
2010
Tipo del documento:
Artículo
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