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A Phase II Trial of Combination Chemotherapy with Cisplatin & Etoposide in Small Cell Lung Cancer / 결핵
Tuberculosis and Respiratory Diseases ; : 632-643, 1994.
Artículo en Coreano | WPRIM | ID: wpr-199675
ABSTRACT

BACKGROUND:

The objective responses of cisplatin and etoposide (PVP) combination chemotherapy as second-line therapy following CAV was high (40~50%) and, in several reports, PVP yields survival results that are at least as good as those obtained with cyclophosphamide or doxorubicin-based regimens and with less host-related toxicity in chemotherapy-naive patients. We conducted a phase II study to evaluate the effect of a combination of cisplatin and etoposide as a first-line therapy in patients with small cell lung cancer.

METHODS:

Sixty-one previously untreated small cell lung cancer patients with measurable lesion(s) received cisplatin(30 mg/m2 IV, day 1~3) and etoposide(100 mg/m2 IV, day 1~3). In patients with limited disease, after completion of 6 cycles of PVP chemotherapy, chest and prophylatic brain irradiation was performed in case of complete responder, chest irradiation only in partial responder.

RESULTS:

1) Of 55 evaluable patients, 13(24%) had a complete response and 29(53%) had a partial response. 2) The median survival time was 55.8 weeks for all patients(N=55), 61.1 weeks for limited disease(N=31), 51.3 weeks for extensive disease(N=24). 3) The response duration was 29.1 weeks for responders(N=42). 4) There was no significant prognostic factors iufluencing response rates. 5) The toxicity was tolerable and there was no treatment-related deaths.

CONCLUSION:

The PVP combination chemotherapy as a first-line therapy was effective and well-tolerated in patients with small cell lung cancer.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Tórax / Encéfalo / Cisplatino / Ciclofosfamida / Quimioterapia / Quimioterapia Combinada / Etopósido / Carcinoma Pulmonar de Células Pequeñas Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Coreano Revista: Tuberculosis and Respiratory Diseases Año: 1994 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Tórax / Encéfalo / Cisplatino / Ciclofosfamida / Quimioterapia / Quimioterapia Combinada / Etopósido / Carcinoma Pulmonar de Células Pequeñas Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Coreano Revista: Tuberculosis and Respiratory Diseases Año: 1994 Tipo del documento: Artículo