The requirement of natural killer T-cells in tolerogenic APCs-mediated suppression of collagen-induced arthritis
Experimental & Molecular Medicine
;
: 547-554, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-200111
ABSTRACT
TGF-beta-induced tolerogenic-antigen presenting cells (Tol-APCs) could induce suppression of autoimmune diseases such as collagen-induced arthritis (CIA) and allergic asthma. In contrast, many studies have shown that NKT cells are involved in the pathogenesis of Th1-mediated autoimmune joint inflammation and Th2-mediated allergic pulmonary inflammation. In this study, we investigated the effect of CD1d-restricted NKT cells in the Tol-APCs-mediated suppression of autoimmune disease using a murine CIA model. When CIA-induced mice were treated with Tol-APCs obtained from CD1d+/- or CD1d-/- mice, unlike CD1d+/- APCs, CD1d-/- Tol-APCs failed to suppress CIA. More specifically, CD1d-/- Tol-APCs failed to suppress the production of inflammatory cytokines and the induction of Th2 responses by antigen-specific CD4 T cells both in vitro and in vivo. Our results demonstrate that the presence of CD1d-restricted NKT cells is critical for the induction of Tol-APCs-mediated suppression of CIA.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Artritis Experimental
/
Citocinas
/
Células TH1
/
Mediadores de Inflamación
/
Colágeno Tipo II
/
Células T Asesinas Naturales
/
Antígenos CD1d
/
Tolerancia Inmunológica
/
Anticuerpos
/
Formación de Anticuerpos
Límite:
Animales
Idioma:
Inglés
Revista:
Experimental & Molecular Medicine
Año:
2010
Tipo del documento:
Artículo
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