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Optimal Time to Start Peripheral Blood Stem Cell Collection in Children with High-Risk Solid Tumors
Journal of Korean Medical Science ; : 110-116, 2014.
Artículo en Inglés | WPRIM | ID: wpr-200218
ABSTRACT
In order to clarify the optimal timing for peripheral blood stem cell (PBSC) collection, PBSC collection records of 323 children who were scheduled to undergo autologous stem cell transplantation from two study periods differing in the timing of PBSC collection were analyzed. In the early study period (March 1998 to August 2007, n=198), PBSC collection was initiated when the peripheral WBC count exceeded 1,000/microL during recovery from chemotherapy. Findings in this study period indicated that initiation of PBSC collection at a higher WBC count might result in a greater CD34+ cell yield. Therefore, during the late study period (September 2007 to December 2012, n=125), PBSC collection was initiated when the WBC count exceeded 4,000/microL. Results in the late study period validated our conclusion from the early study period. Collection of a higher number of CD34+ cells was associated with a faster hematologic recovery after transplant in the late study period. Initiation of PBSC collection at WBC count > 4,000/microL was an independent factor for a greater CD34+ cell yield. In conclusion, PBSC collection at a higher WBC count is associated with a greater CD34+ cell yield, and consequently a faster hematologic recovery after transplant.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Trasplante Autólogo / Células Madre Hematopoyéticas / Factor Estimulante de Colonias de Granulocitos / Trasplante de Células Madre Hematopoyéticas / Antígenos CD34 / Recuento de Leucocitos / Neoplasias / Antineoplásicos Tipo de estudio: Estudio de etiología Límite: Adolescente / Adulto / Niño / Child, preschool / Femenino / Humanos / Lactante / Masculino Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Trasplante Autólogo / Células Madre Hematopoyéticas / Factor Estimulante de Colonias de Granulocitos / Trasplante de Células Madre Hematopoyéticas / Antígenos CD34 / Recuento de Leucocitos / Neoplasias / Antineoplásicos Tipo de estudio: Estudio de etiología Límite: Adolescente / Adulto / Niño / Child, preschool / Femenino / Humanos / Lactante / Masculino Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2014 Tipo del documento: Artículo