Retroperitoneal Castleman's Disease with Pure Red Cell Aplasia

ABSTRACT

Castleman's disease is a distinct lymphoproliferative disorder of unknown origin, which creates both a diagnostic and therapeutic dilemma for most physicians. Here, we present a case of hyaline-vascular and solitary Castleman's disease associated with pure red cell aplasia. A 49-year old woman was admitted suffering from severe anemia. A bone marrow biopsy showed marked erythroid hypoplasia. A solitary retroperitoneal mass was excised and proven to be Castleman's disease with hyaline-vascular type histology. Removal of the mass led to a rapid reversal of anemia. No evidence of recurrence was found 1 year after the excision.