The Role of the Ethylacetate Fraction from Hydnocarpi Semen in Acute Inflammation In Vitro Model
Immune Network
;
: 291-295, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-20062
ABSTRACT
We previously reported that Hydnocarpi Semen (HS) has a wound healing effect on diabetic foot ulcer lesion in mice. In this study, ethylacetate (EtOAc) fraction from HS extract were evaluated for their wound healing activity by using in vitro acute inflammation model. GC and GC/MS analysis shows that the main constituents in EtOAc fraction are chaulmoogric acid, hydnocarpic acid, and gorlic acid. EtOAc fraction activated macrophages to increase the production of TNF-alpha. The fraction also increased the production of TGF-beta and VEGF, which induced fibroblast activation and angiogenesis. These results suggest that the mechanism that the fraction helps to enhance healing of skin wound is possibly associated with the production of TNF-alpha, as well as secretion of VEGF, TGF-beta and HS may have a new bioactive material for the treatment of skin wound.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Semen
/
Piel
/
Úlcera
/
Cicatrización de Heridas
/
Citocinas
/
Factor de Crecimiento Transformador beta
/
Factor de Necrosis Tumoral alfa
/
Pie Diabético
/
Factor A de Crecimiento Endotelial Vascular
/
Ácidos Grasos
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Immune Network
Año:
2012
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS