Alternatively activated M2 macrophages increase in early stages of experimental autoimmune myocarditis in Lewis rats / 대한수의학회지
Korean Journal of Veterinary Research
;
: 225-230, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-200775
ABSTRACT
To better understand the role of macrophages in early stages of experimental autoimmune myocarditis (EAM), we compared the expression of inducible nitric oxide synthase (iNOS) and arginase-1, markers for classically activated M1 and alternatively activated M2 macrophages, respectively, in the hearts of EAM-affected and control rats. Immunohistochemical evidence revealed that both iNOS-positive and arginase 1-positive macrophages were found in EAM lesions, while some cells were co-localized with both markers. This finding suggests that the increased level of arginase-1, which is partly from M2 macrophages, contributes to the modulation of EAM, possibly through the reduction of nitric oxide in the lesion.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Arginasa
/
Óxido Nítrico Sintasa de Tipo II
/
Corazón
/
Macrófagos
/
Miocarditis
/
Óxido Nítrico
Límite:
Animales
Idioma:
Inglés
Revista:
Korean Journal of Veterinary Research
Año:
2013
Tipo del documento:
Artículo
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