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Comparison of coagulation factors and blood loss between O and non-O blood types following hydroxyethyl starch infusion / 대한마취과학회지
Korean Journal of Anesthesiology ; : 344-350, 2010.
Artículo en Inglés | WPRIM | ID: wpr-200862
ABSTRACT

BACKGROUND:

Individuals with type O blood are more likely to have reduced factor VIII and von Willebrand factor levels compared to their non-O counterparts. Hydroxyethyl starch (HES), which is widely used for blood volume replacement, can induce coagulopathy. Therefore, we tested whether blood type O patients show more coagulopathy and blood loss than non-O patients after infusion of 6% HES.

METHODS:

Thirty-four non-O and 20 type O patients scheduled for posterior lumbar interbody fusion (PLIF) involving 3 vertebrae or less from June 2007 to August 2008 were enrolled. Fifteen ml/kg of 6% HES was administered during the operation. Coagulation profiles was checked at pre-infusion (T0), 5 min after the end of infusion (T1), 3 hr after the end of infusion (T2), and 24 hr after the end of infusion (T3). Bleeding was measured during and after surgery for 24 hours.

RESULTS:

Baseline factor VIII concentration was lower and aPTT was longer in type O patients compared to those of non-O patients. 6% HES infusion decreased most of the coagulation factors at T1 in both groups, which were recovered in a time dependent manner. Factor VIII and aPTT of blood type O patients fell off the normal range at T1. However, other coagulation factors, thromboelastography variables, and blood loss were not different between the groups.

CONCLUSIONS:

Despite inborn low factor VIII which further decreased shortly after HES infusion, blood type O patients did not show more blood loss than non-O blood type after 15 ml/kg of HES infusion in PLIF surgery.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Valores de Referencia / Columna Vertebral / Tromboelastografía / Volumen Sanguíneo / Factores de Coagulación Sanguínea / Factor VIII / Factor de von Willebrand / Derivados de Hidroxietil Almidón / Hemorragia Límite: Humanos Idioma: Inglés Revista: Korean Journal of Anesthesiology Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Valores de Referencia / Columna Vertebral / Tromboelastografía / Volumen Sanguíneo / Factores de Coagulación Sanguínea / Factor VIII / Factor de von Willebrand / Derivados de Hidroxietil Almidón / Hemorragia Límite: Humanos Idioma: Inglés Revista: Korean Journal of Anesthesiology Año: 2010 Tipo del documento: Artículo