Recurrent Pseudomonas aeruginosa Infection in Chronic Lung Diseases: Relapse or Reinfection? / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 172-177, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-200945
ABSTRACT
BACKGROUND:
Pseudomonas aeruginosa infection is particularly associated with progressive and ultimately chronic recurrent respiratory infections in chronic obstructive pulmonary disease, bronchiectasis, chronic destroyed lung disease, and cystic fibrosis. Its treatment is also very complex because of drug resistance and recurrence.METHODS:
Forty eight cultures from 18 patients with recurrent P. aeruginosa pneumonia from 1998 to 2002 were included in this study. Two or more pairs of sputum cultures were performed during 2 or more different periods of recurrences. The comparison of strains was made according to the phenotypic patterns of antibiotic resistance and chromosomal fingerprinting by pulsed field gel electrophoresis (PFGE) using the genomic DNA of P. aeruginosa from the sputum culture.RESULTS:
Phenotypic patterns of antibiotic resistance of P. aeruginosa were not correlated with their prior antibiotic exposition. Fifteen of 18 patients (83.3%) had recurrent P. aeruginosa pneumonia caused by the strains with same PFGE pattern.CONCLUSION:
These data suggest that the most of the recurrent P. aeruginosa infections in chronic lung disease occurred due to the relapse of prior infections. Further investigations should be performed for assessing the molecular mechanisms of the persistent colonization and for determining how to eradicate clonal persistence of P. aeruginosa.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neumonía
/
Pseudomonas aeruginosa
/
Recurrencia
/
Infecciones del Sistema Respiratorio
/
Esputo
/
Bronquiectasia
/
ADN
/
Resistencia a Medicamentos
/
Farmacorresistencia Microbiana
/
Electroforesis en Gel de Campo Pulsado
Límite:
Humanos
Idioma:
Inglés
Revista:
Tuberculosis and Respiratory Diseases
Año:
2014
Tipo del documento:
Artículo
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