Drug Therapy for Alzheimer's Disease
Journal of the Korean Medical Association
;
: 369-374, 2007.
Artículo
en Coreano
| WPRIM
| ID: wpr-200969
ABSTRACT
Alzheimer's disease (AD) is the most common cause of dementia in the elderly. AD afflicts 0.3 to 0.5 million people in Korea, and the number is projected to increase to 2 million by the year of 2050. This article provides a brief overview of the most popular drug therapies in the treatment of AD including cholinesterase inhibitors (AchEIs) (donepezil, galantamine, rivastigmine), NMDA receptor antagonist (memantine), acetyl-l-carnitine, antioxidant vitamins, and Ginko biloba. Based on a review of relevant papers in the literature, this article presents pharmacological and clinical safety profiles of these agents and prescribing tips as well as a final summary on the effectiveness, safety, and alerts for clinicians. AchEIs as well as memantine will continue to play an important role in the treatment armamentarium for AD, even though newer strategies are being explored. There is not enough evidence supporting the continuous use of other drugs such as acetyl-l-carnitine, antioxidant vitamins, and Ginko biloba for the treatment of AD.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Acetilcarnitina
/
Vitaminas
/
Memantina
/
Inhibidores de la Colinesterasa
/
N-Metilaspartato
/
Ginkgo biloba
/
Demencia
/
Quimioterapia
/
Enfermedad de Alzheimer
/
Galantamina
Límite:
Anciano
/
Humanos
País/Región como asunto:
Asia
Idioma:
Coreano
Revista:
Journal of the Korean Medical Association
Año:
2007
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS