The role of sex steroid hormones in the pathophysiology and treatment of sarcopenia
Osteoporosis and Sarcopenia
;
: 140-155, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-201247
ABSTRACT
Sex steroids influence the maintenance and growth of muscles. Decline in androgens, estrogens and progesterone by aging leads to the loss of muscular function and mass, sarcopenia. These steroid hormones can interact with different signaling pathways through their receptors. To date, sex steroid hormone receptors and their exact roles are not completely defined in skeletal and smooth muscles. Although numerous studies focused on the effects of sex steroid hormones on different types of cells, still many unexplained molecular mechanisms in both skeletal and smooth muscle cells remain to be investigated. In this paper, many different molecular mechanisms that are activated or inhibited by sex steroids and those that influence the growth, proliferation, and differentiation of skeletal and smooth muscle cells are reviewed. Also, the similarities of cellular and molecular pathways of androgens, estrogens and progesterone in both skeletal and smooth muscle cells are highlighted. The reviewed signaling pathways and participating molecules can be targeted in the future development of novel therapeutics.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Progesterona
/
Hormonas Esteroides Gonadales
/
Esteroides
/
Envejecimiento
/
Músculo Esquelético
/
Miocitos del Músculo Liso
/
Estrógenos
/
Sarcopenia
/
Andrógenos
/
Músculo Liso
Idioma:
Inglés
Revista:
Osteoporosis and Sarcopenia
Año:
2016
Tipo del documento:
Artículo
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