Effects of retinoic acid on ischemic brain injury-induced eurogenesis
Experimental & Molecular Medicine
;
: 304-315, 2007.
Artículo
en Inglés
| WPRIM
| ID: wpr-201424
ABSTRACT
Neurogenesis can be induced by pathological conditions such as cerebral ischemia. However the molecular mechanisms or modulating reagents of the reactive neurogenesis after the cerebral ischemia are poorly characterized. Retinoic acid (RA) has been shown to increase neurogenesis by enhancing the proliferation and neuronal differentiation of forebrain neuroblasts. Here, we examined whether RA can modulate the reactive neurogenesis after the cerebral ischemia. In contrast to our expectation, RA treatment decreased the reactive neurogenesis in subventricular zone (SVZ), subgranular zone (SGZ) and penumbral region. Furthermore, RA treatment also decreased the angiogenesis and gliosis in penumbral region.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tretinoina
/
Encéfalo
/
Diferenciación Celular
/
Ataque Isquémico Transitorio
/
Neuroglía
/
Ratas Sprague-Dawley
/
Proliferación Celular
/
Neovascularización Patológica
/
Neuronas
Límite:
Animales
Idioma:
Inglés
Revista:
Experimental & Molecular Medicine
Año:
2007
Tipo del documento:
Artículo
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