Thrombotic Microangiopathy during Ganciclovir Treatment for Cytomegalovirus Infection in a Patient with Autologous Hematopoietic Stem Cell Transplantation / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
;
: 161-164, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-201476
ABSTRACT
Thrombotic microangiopathy (TMA) is a known complication of hematopoietic stem cell transplantation (HSCT). Here, we describe a case of TMA after autologous HSCT, which was associated with ganciclovir treatment. A 5-year-old boy presented with Coombs-negative hemolytic anemia, thrombocytopenia, gross hematuria, massive proteinuria, and hypertension during ganciclovir treatment after autologous HSCT. TMA was confirmed by renal biopsy which showed swelling of endothelial cells, occlusion of the glomerular lumina, duplication of glomerular basement membranes, and mesangiolysis. There was complete resolution of TMA in both laboratory and clinical manifestations after ganciclovir cessation only with supportive cares and hydration.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Proteinuria
/
Trombocitopenia
/
Biopsia
/
Células Madre Hematopoyéticas
/
Ganciclovir
/
Preescolar
/
Infecciones por Citomegalovirus
/
Trasplante de Células Madre Hematopoyéticas
/
Citomegalovirus
/
Células Endoteliales
Límite:
Humanos
Idioma:
Inglés
Revista:
Clinical Pediatric Hematology-Oncology
Año:
2011
Tipo del documento:
Artículo
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