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The Expression of Matrix Metalloproteinase-9 and Tumor Angiogenesis in Human Osteosarcoma
Korean Journal of Pathology ; : 418-423, 2005.
Artículo en Inglés | WPRIM | ID: wpr-201582
ABSTRACT

BACKGROUND:

Matrix metalloproteinase-9 (MMP-9) is a matrix-degrading enzyme that's believed to play a crucial role not only for tumor invasion and metastasis, but also for a variety of stromal reactions, including neovascularization. The aim of this study was to investigate the expression of MMP-9 and to compare its expression with the angiogenesis activity in human osteosarcoma.

METHODS:

Archival tumor tissue samples from 20 patients with osteosarcoma were analyzed by performing immunohistochemistry for the expression of MMP-9 and CD34. The vascularity was measured as the average microvascular density (MVD) of the CD34-positive vessels. The clinical information was obtained through searching the computerized retrospective database from the tumor registry.

RESULTS:

MMP-9 was expressed in 90% (18/20) of the tumors we examined. The MVD ranged from 10.5 to 179.7 with a mean of 64.9. There was no significant correlation between the MMP-9 expression and the MVD (p=.613). The MMP-9 expression was not associated with any of the clinicopathologic variables, whereas the MVD showed an increasing tendency according to the metastasis status (p=.073).

CONCLUSIONS:

We demonstrated that MMP-9 activation is likely to occur in human osteosarcoma. However, there was no direct involvement of MMP-9 with tumor angiogenesis. It is noteworthy that MVD may aid physicians to predict the presence of distant metastasis in osteosarcoma patients.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Inmunohistoquímica / Osteosarcoma / Estudios Retrospectivos / Metaloproteinasa 9 de la Matriz / Metástasis de la Neoplasia Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Korean Journal of Pathology Año: 2005 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Inmunohistoquímica / Osteosarcoma / Estudios Retrospectivos / Metaloproteinasa 9 de la Matriz / Metástasis de la Neoplasia Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Korean Journal of Pathology Año: 2005 Tipo del documento: Artículo