Longitudinal study of specific antibodies to toluene diisocyanate (TDI)-human serum albumin (HSA) conjugate in patients with TDI-induced asthma
The Korean Journal of Internal Medicine
;
: 249-251, 2002.
Artículo
en Inglés
| WPRIM
| ID: wpr-20180
ABSTRACT
BACKGROUND:
An appreciable number of patients with toluene diisocyanate (TDI)-induced asthma have high serum levels of specific IgE (sIgE) antibody to TDI-human serum albumin conjugate (HSA). A recent investigation suggested a role of specific IgG (sIgG) in the development of TDI asthma.METHODS:
We observed the changes in the levels of specific IgE and IgG antibodies to TDIHSA conjugate in TDI-induced asthmatic patients during seven years avoidance.RESULTS:
Six subjects with high sIgE and five with high sIgG were enrolled. All of them had taken anti-asthmatic medications with complete avoidance. Serum levels of sIgE and sIgG to TDI-HSA conjugate were detected by ELISA. The level of sIgE continued to decline up to 7 years and the mean half-life was 3.9 years. The mean half-life of sIgG was 4.5 yrs.CONCLUSION:
These findings suggest that both sIgE and sIgG to TDI-HSA conjugate may persist for several years after the last exposure to TDI.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Asma
/
Inmunoglobulina E
/
Inmunoglobulina G
/
Albúmina Sérica
/
Biomarcadores
/
Estudios Longitudinales
/
2,4-Diisocianato de Tolueno
Tipo de estudio:
Estudio observacional
Límite:
Adulto
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
The Korean Journal of Internal Medicine
Año:
2002
Tipo del documento:
Artículo
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