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Longitudinal study of specific antibodies to toluene diisocyanate (TDI)-human serum albumin (HSA) conjugate in patients with TDI-induced asthma
The Korean Journal of Internal Medicine ; : 249-251, 2002.
Artículo en Inglés | WPRIM | ID: wpr-20180
ABSTRACT

BACKGROUND:

An appreciable number of patients with toluene diisocyanate (TDI)-induced asthma have high serum levels of specific IgE (sIgE) antibody to TDI-human serum albumin conjugate (HSA). A recent investigation suggested a role of specific IgG (sIgG) in the development of TDI asthma.

METHODS:

We observed the changes in the levels of specific IgE and IgG antibodies to TDIHSA conjugate in TDI-induced asthmatic patients during seven years avoidance.

RESULTS:

Six subjects with high sIgE and five with high sIgG were enrolled. All of them had taken anti-asthmatic medications with complete avoidance. Serum levels of sIgE and sIgG to TDI-HSA conjugate were detected by ELISA. The level of sIgE continued to decline up to 7 years and the mean half-life was 3.9 years. The mean half-life of sIgG was 4.5 yrs.

CONCLUSION:

These findings suggest that both sIgE and sIgG to TDI-HSA conjugate may persist for several years after the last exposure to TDI.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Asma / Inmunoglobulina E / Inmunoglobulina G / Albúmina Sérica / Biomarcadores / Estudios Longitudinales / 2,4-Diisocianato de Tolueno Tipo de estudio: Estudio observacional Límite: Adulto / Humanos / Masculino Idioma: Inglés Revista: The Korean Journal of Internal Medicine Año: 2002 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Asma / Inmunoglobulina E / Inmunoglobulina G / Albúmina Sérica / Biomarcadores / Estudios Longitudinales / 2,4-Diisocianato de Tolueno Tipo de estudio: Estudio observacional Límite: Adulto / Humanos / Masculino Idioma: Inglés Revista: The Korean Journal of Internal Medicine Año: 2002 Tipo del documento: Artículo