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The Changes of Arterial Ketone Body Ratio and Osmolal Gap during Hemorrhagic Shock in Rabbit / 대한마취과학회지
Korean Journal of Anesthesiology ; : 421-427, 1994.
Artículo en Coreano | WPRIM | ID: wpr-201822
ABSTRACT
The ratio of acetoacetate to 8-hydroxybutyrate (ketone body ratio) in the blood may reflects the mitochondrial free NAD+/NADH ratio in the liver. Also arterial ketone body ratio will reflects the energy status of the hepatocytes, because mitochondrial free NAD+/NADH ratio is closely related to oxidative phosphorylation. Arterial ketone body ratio and osmolal gap, the difference between measured osmolality and calculated osmolality, were measured 30 min after the induction of hemorrhagic shock with mean arterial blood pressure at 40 mmHg in ten rabbits. Arterial ketone body ratios decreased significantly (p<0.05) from 0.74+/-0.17 to 0.38+/-0.09 and osmolal gap increased significantly (p<0.05) from 17.7+/-5.9 mOsm/Kg to 32.8+/-12.3 mOsm/Kg at 30 min after the induction of hemorrhagic shock. These results suggest that in hemorrhagic shock, decreased arterial ketone body ratio which reflects the inhibition of the TCA cycle is associated with increase of osmolal gap.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Concentración Osmolar / Fosforilación Oxidativa / Choque Hemorrágico / Hepatocitos / Presión Arterial / Hígado Límite: Animales Idioma: Coreano Revista: Korean Journal of Anesthesiology Año: 1994 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Concentración Osmolar / Fosforilación Oxidativa / Choque Hemorrágico / Hepatocitos / Presión Arterial / Hígado Límite: Animales Idioma: Coreano Revista: Korean Journal of Anesthesiology Año: 1994 Tipo del documento: Artículo