Anti-Inflammatory Effects of Water Chestnut Extract on Cytokine Responses via Nuclear Factor-kappaB-signaling Pathway
Biomolecules & Therapeutics
;
: 90-97, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-202114
ABSTRACT
Water chestnut (Trapa japonica Flerov.) is an annual aquatic plant. In the present study, we showed that the treatment of water chestnut extracted with boiling water resulted in a significant increase 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity and decrease the intracellular H2O2-induced accumulation of reactive oxygen species. In addition, water chestnut extract (WCE) inhibited lipopolysaccharide (LPS)-induced nitric oxide production and suppressed mRNA and protein expression of the inducible nitric oxide synthase gene. The cytokine array results showed that WCE inhibited inflammatory cytokine secretion. Also, WCE reduced tumor necrosis factor-alpha- and interleukin-6-induced nuclear factor-kappaB activity. Furthermore, during sodium lauryl sulfate (SLS)-induced irritation of human skin, WCE reduced SLS-induced skin erythema and improved barrier regeneration. These results indicate that WCE may be a promising topical anti-inflammatory agent.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plantas
/
Regeneración
/
Piel
/
Dodecil Sulfato de Sodio
/
ARN Mensajero
/
FN-kappa B
/
Especies Reactivas de Oxígeno
/
Eleocharis
/
Eritema
/
Óxido Nítrico Sintasa de Tipo II
Límite:
Humanos
Idioma:
Inglés
Revista:
Biomolecules & Therapeutics
Año:
2015
Tipo del documento:
Artículo
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