The clinical performance of APTIMA human papillomavirus and Hybrid Capture 2 assays in the triage of lesser abnormal cervical cytologies / 부인종양
Journal of Gynecologic Oncology
;
: 287-292, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-202223
ABSTRACT
OBJECTIVE:
This study was performed to evaluate the clinical performance of APTIMA human papillomavirus (AHPV) assay and Hybrid Capture 2 (HC2) assay in screening for cervical disease, especially in women with atypical squamous cell of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesion (LSIL).METHODS:
A total of 411 women diagnosed with ASC-US or LSIL were referred and further triaged by HC2 test. Prior to colposcopy, liquid-based cytology specimens were collected for the AHPV assay. Sensitivity and specificity were established based on the histological findings of cervical intraepithelial neoplasia (CIN).RESULTS:
In all 411 subjects, the positive detection rate of AHPV assay was 70.8% (95% confidence interval [CI], 66.4 to 75.2), which was significantly lower than the positive detection rate of 94.9% obtained using HC2 test (95% CI, 92.3 to 96.8). Only one CIN 3-positive case was detected among the 120 AHPV-negative women, which was then confirmed by Pap smear test to be LSIL. The sensitivities of AHPV and HC2 for CIN 3 were similar (94.1% and 100%, respectively). However, AHPV showed a significantly higher specificity than HC2 test (30.2% and 5.3%, respectively; p<0.001).CONCLUSION:
AHPV assay is effective in identifying CIN 3-positive cases because of its high specificity and lower false-negative rate. The use of AHPV for the triage of ASC-US and LSIL might help to reduce the referral rate of colposcopy during cervical cancer screening.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Displasia del Cuello del Útero
/
Neoplasias del Cuello Uterino
/
China
/
Prevalencia
/
Triaje
/
Sensibilidad y Especificidad
/
Colposcopía
/
Infecciones por Papillomavirus
/
Reacciones Falso Negativas
/
Detección Precoz del Cáncer
Tipo de estudio:
Estudio diagnóstico
/
Estudio de prevalencia
/
Estudio pronóstico
/
Estudio de tamizaje
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Journal of Gynecologic Oncology
Año:
2014
Tipo del documento:
Artículo
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