Neuroprotective Effects of a Butanol Fraction of Rosa hybrida Petals in a Middle Cerebral Artery Occlusion Model
Biomolecules & Therapeutics
;
: 454-461, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-202594
ABSTRACT
The neuroprotective effects of a butanol fraction of white rose petal extract (WRPE-BF) were investigated in a middle cerebral artery occlusion (MCAO) model. Seven week-old male rats were orally administered WRPE-BF for 2 weeks and subjected to MCAO for 2 h, followed by reperfusion. Twenty-four h later, MCAO-induced behavioral dysfunctions were markedly improved in a dose-dependent manner by pretreatment with WRPE-BF. Moreover, higher dose of WRPE-BF not only decreased infarction area but also effectively reduced astrogliosis. The expression of inducible nitric oxide synthase, cyclooxygenase-2, and glial fibrillary acidic protein in MCAO model were markedly inhibited by WRPE-BF treatment. Notably, WRPE-BF decreased nitric oxide and malondialdehyde levels in the striatum and subventricular zone of stroke-challenged brains. These data suggested that WRPE-BF may exert its neuroprotective effects via anti-oxidative and anti-inflammatory activities against ischemia-reperfusion brain injury and could be a good candidate as a therapeutic target for ischemic stroke.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Encéfalo
/
Lesiones Encefálicas
/
Reperfusión
/
Fármacos Neuroprotectores
/
Arteria Cerebral Media
/
Accidente Cerebrovascular
/
Infarto de la Arteria Cerebral Media
/
Rosa
/
Ciclooxigenasa 2
/
Óxido Nítrico Sintasa de Tipo II
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Biomolecules & Therapeutics
Año:
2013
Tipo del documento:
Artículo
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