Multiple Hepatic and Paraaortic Lymph Nodes Metastases from Advanced Gastric Cancer Successfully Treated with Oxaliplatin/Leucovorin/5-FU

ABSTRACT

The treatment for the hepatic and lymph nodes metastases after curative resection of gastric cancer has not yet been established. The different kinds of treatment that have been attempted have not yet shown satisfactory results. We report here on a case of an advanced gastric cancer patient who had multiple hepatic and paraaortic lymph node metastases 4 months after curative resection, and the woman showed a clinical response of complete remission to combination chemotherapy with oxaliplatin, leucovorin and 5-FU. A 62-year-old female patient, who was diagnosed with Borrmann type 3 advanced gastric cancer, underwent distal gastrectomy and D2 lymph nodes dissection. The conclusive stage was stage IIIA After UFT 400 mg/m(2) was administered for 4 months, abdominal CT scan revealed two hepatic metastases and multiple paraaortic nodal enlargements. She received combination chemotherapy with oxaliplatin 100 mg/m(2) and LV 100 mg/m(2) for a 2-hour infusion at day 1, followed by a 22-hour continuous infusion of 5-FU 1,750 mg/m(2) at days 1 and 2. She remains alive without any evidence of recurrent disease for 47 months after chemotherapy.