Effects of Renin-angiotensin System Blockade on Tubulointerstitial Lesions in Adriamycin-induced Nephropathy / 대한신장학회잡지
Korean Journal of Nephrology
;
: 26-31, 2005.
Artículo
en Coreano
| WPRIM
| ID: wpr-203780
ABSTRACT
PURPOSE:
Effects of renin-angiotensin system blockade on tubulointerstitial lesions were examined in adriamycin-induced nephropathy.METHODS:
Male Sprague-Dawley rats were used. The three experimental groups were intravenously injected with adriamycin (2 mg/kg). After 6 weeks, rats showing heavy proteinuria were orally treated with either cilazapril 1 mg/kg/day (ACEi group, n=7) or losartan 10 mg/kg/day (ARB group, n=7) during the period of additional 6 weeks. The other group was maintained without any drugs (ADR group, n=6). The control group was without adriamycin treatment and maintained during the 12 weeks (Control, n=5).RESULTS:
Systolic blood pressure was increased following the adriamycin treatment, which was normalized by treatment with cilazapril or losartan. Accordingly, cilazapril and losartan normalized the 24-h urine protein/creatinine ratio, in association with morphologic improvement of tubulointerstitial lesions. The expression of laminin beta1 was not altered in any experimental groups.CONCLUSION:
These results suggest that angiotensin II plays an important role in tubulointerstitial lesions in adriamycin-induced nephropathy.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Proteinuria
/
Sistema Renina-Angiotensina
/
Presión Sanguínea
/
Angiotensina II
/
Doxorrubicina
/
Laminina
/
Ratas Sprague-Dawley
/
Cilazapril
/
Losartán
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Nephrology
Año:
2005
Tipo del documento:
Artículo
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