Additive Effect of Pronase on the Eradication Rate of First-Line Therapy for Helicobacter pylori Infection
Gut and Liver
;
: 340-345, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-203893
ABSTRACT
BACKGROUND/AIMS:
Helicobacter pylori colonizes on the apical surface of gastric surface mucosal cells and the surface mucous gel layer. Pronase is a premedication enzyme for endoscopy that can disrupt the gastric mucus layer. We evaluated the additive effects of pronase combined with standard triple therapy for H. pylori eradication.METHODS:
This prospective, single-blinded, randomized, controlled study was conducted between June and October 2012. A total of 116 patients with H. pylori infection were enrolled in the study (n=112 patients, excluding four patients who failed to meet the inclusion criteria) and were assigned to receive either the standard triple therapy, which consists of a proton pump inhibitor with amoxicillin and clarithromycin twice a day for 7 days (PAC), or pronase (20,000 tyrosine units) combined with the standard triple therapy twice a day for 7 days (PACE).RESULTS:
In the intention-to-treat analysis, the eradication rates of PAC versus PACE were 76.4% versus 56.1% (p=0.029). In the per-protocol analysis, the eradication rates were 87.5% versus 68.1% (p=0.027). There were no significant differences concerning adverse reactions between the two groups.CONCLUSIONS:
According to the interim analysis of the trial, pronase does not have an additive effect on the eradication of H. pylori infection (ClinicalTrial.gov NCT01645761).
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Esquema de Medicación
/
Pronasa
/
Método Simple Ciego
/
Estudios Prospectivos
/
Helicobacter pylori
/
Infecciones por Helicobacter
/
Resultado del Tratamiento
/
Claritromicina
/
Quimioterapia Combinada
/
Inhibidores de la Bomba de Protones
Tipo de estudio:
Ensayo Clínico Controlado
/
Guía de Práctica Clínica
/
Estudio observacional
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Gut and Liver
Año:
2015
Tipo del documento:
Artículo
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