Treatment of Aplasia Cuti Congenita Using Allogenic Dermal matrix and Cultured Epithelial Autograft : A Case Report

ABSTRACT

PURPOSE: The purpose of this study is to document the surgical methods used in infants with aplasia cutis congenita treated with allogenic dermal matrix and cultured epithelial autografts. METHODS: The large defects in both lower legs were replaced with allogenic dermal matrix to avoid the postoperative hypertrophic scar contracture and a full- thickness skin biopsy was taken from right groin area simultaneously. We sent the specimen to a commercial laboratory for culture and obtained cultured epithelial autografts(Holoderm(R)) after 2 weeks, placed it over the allogenic dermal matrix. RESULTS: The skin-defected area were nearly epithelialized after 2 weeks and there were no significant problem on during 6 months follow-up. CONCLUSION: The surgical method using allogenic dermal matrix and cultured epithelial autograft provided an excellent coverage of large skin defects of infant with aplasia cutis congenita.