Reticulocyte hemoglobin content for the diagnosis of iron deficiency in young children with acute infection / 소아과
Korean Journal of Pediatrics
;
: 827-833, 2008.
Artículo
en Coreano
| WPRIM
| ID: wpr-204319
ABSTRACT
PURPOSE:
Early identification of iron deficiency in young children is essential to prevent damaging long-term consequences. It is often difficult for the pediatrician to know which indices should be used when diagnosing these conditions especially in hospitalized young children. This study investigated the clinical significances of reticulocyte hemoglobin content in young children with acute infection.METHODS:
We studied 69 young children aged from 6 to 24 months admitted with acute infection in a single center. Venous blood was drawn to determine hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), hemoglobin content (CH), reticulocyte hemoglobin content (CHr), and red blood cell distribution width (RDW) using ADVIA 120 (Bayer Diagnostics, NY, USA). For evaluating iron status, iron, total iron binding capacity, ferritin and transferrin saturation (Tfsat) were determined. Iron deficiency was defined as Tfsat less than 20%, and iron deficiency anemia as Tfsat less than 20% and Hb level less than 11 g/dL.RESULTS:
In all, 47 were iron deficient; 17 of these had iron deficiency anemia. CHr was the only significant predictor of iron deficiency (likelihood ratio test=71.25; odds ratio=0.67; P<0.05). Plasma ferritin level had no predictive value (P=0.519). Subjects with CHr less than 27.4 pg had lower Hb level, MCH, CH, Tfsat, and iron levels than those with CHr 27.4 pg or more (P<0.05 for all).CONCLUSION:
CHr level was a sensitive screening tool and the strongest predictor of iron deficiency in hospitalized infants with acute infection; it was cost saving and avoiding additional sampling. However its reference range should be established.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plasma
/
Valores de Referencia
/
Reticulocitos
/
Hemoglobinas
/
Transferrina
/
Tamizaje Masivo
/
Ahorro de Costo
/
Anemia Ferropénica
/
Índices de Eritrocitos
/
Eritrocitos
Tipo de estudio:
Estudio diagnóstico
/
Estudio de tamizaje
Límite:
Anciano
/
Niño
/
Humanos
/
Lactante
Idioma:
Coreano
Revista:
Korean Journal of Pediatrics
Año:
2008
Tipo del documento:
Artículo
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